The 6 Best Hypoallergenic Mattress Covers of 2020

Man Removing Dust From Mattress

With all the free radicals present in the environment today, a hypoallergenic mattress cover is commonly used by people with allergies. It provides an added layer of protection over the mattress and shields the mattress from dust mites, pet dander, and other allergens.

A hypoallergenic mattress cover should fit the size of the mattress accordingly, and the fabric should be tightly woven to prevent dust mites from passing through the fabric.

Best Hypoallergenic Mattress Covers

1. Edilly Premium 100% Waterproof Mattress Pad Protector

EDILLY Queen Size Premium Hypoallergenic 100% Waterproof Mattress Pad Protector Cover Luxury Breathable Fitted 8

The Edilly Queen Size waterproof mattress pad protector truly protects against what a pet or child does on the mattress. It will protect an expensive mattress set. The mattress cover is waterproof, but not breathable, so it may retain odor.

2. SafeRest Premium Hypoallergenic Waterproof Mattress Protector

SafeRest Queen Size Premium Hypoallergenic Waterproof Mattress Protector - Vinyl Free

The SafeRest mattress protector will pool cat urine or other liquid. It leaves no odor behind. It is also spillproof for soda, water, tea, and when children wet the bed. The mattress protector is very noisy, however, and it does not work well with cooling mattress foam mattresses.

3. Hanna Kay Hypoallergenic Quilted Stretch-to-Fit Mattress Pad

Hypoallergenic Quilted Stretch-to-Fit Mattress Pad by Hanna Kay, 10 Year Warranty-Clyne Collection (Queen)

The Hanna Kay mattress cover is a great barrier between you and the mattress. Sweat or urine will not seep through. It also adds a good layer of cushion between the mattress. However, the fit may be off and does not fit a 10-inch queen memory foam mattress well.

4.AirExpect Waterproof Mattress Protector

AirExpect Waterproof Mattress Protector King Size 100% Full Cotton Hypoallergenic Breathable Mattress Pad Cover,18‘’ Deep Pocket, No Vinyl, 76‘’ x 80‘’

Sweat and urine will not penetrate the AirExpect organic mattress cover. It also repels pet dander and hair exceptionally well. The cover is more plastic-like, like old school rubber sheets. It is not ideal if you are going for a certain look and feel for a mattress cover.

5. Linenspa Waterproof Zippered Encasement Protector

Linenspa Zippered Waterproof, Dust Mite, Bed Bug Proof, Queen Size Hypoallergenic Breathable Protector, Mattress Encasement

The Linenspa mattress cover works well for keeping out critters like bed bugs. The plastic material is heavy and durable enough to resist tears without retaining heat or becoming too hot. Unfortunately, water can get through the material if it sits for too long.

6. PlushDeluxe Premium Bamboo Mattress Cover

PlushDeluxe Premium Bamboo Mattress Protector – Waterproof, Hypoallergenic & Ultra Soft Breathable Bed Mattress Cover for Maximum Comfort & Protection - PVC, Phthalate (Queen Size)

The PlushDeluxe mattress cover for cat owners doesn’t shift or move on the mattress when tossing and turning at night. The material is soft and doesn’t allow water or liquids through when it sits for several hours. The protector may not cover the sides of the mattress.

Hypoallergenic Mattress Cover Benefits

  • Keeps allergens, dust mites, other bugs from the mattress.
  • Extends the life of the mattress by providing protection from daily wear and tear.
  • Prevents liquids, dirt, dander, animal hair and fur from coming into contact with the mattress.
  • Using a mattress cover as protection is easier to clean compared to cleaning the mattress itself.

Other Features and Factors To Keep In Mind


A hypoallergenic mattress cover that is waterproof is recommended for families with children and pets, as they are prone to spills and accidents.

Bed Bug Resistant

Mattress covers that are bed bug resistant usually have a zipper on the sides to keep the bed bugs out. It fully encloses the mattress and is non-porous.

Material Used

Cotton, wool, and polyester are the most common fabrics used in hypoallergenic mattress cover. They are allergy-resistant, soft, cozy, and water-resistant.


The mattress cover should feel comfortable, smooth, and not scratchy. It should fit perfectly over the mattress and should not bunch on the edges or corners.


For fitted covers, the edges should cover the whole bed for overall protection. For zipped covers, the zipper should be working properly to ensure that no bed bugs will enter.

Thread Count

A high thread count is expected for hypoallergenic mattress as it translates to better protection. This means that the material is less porous, effectively barring the dirt, dust, and other particles to come through.


A breathable mattress cover is essential as it keeps the body cool, especially in hot and humid weather.

Easy to Wash

A hypoallergenic mattress cover should be washed once a week in hot water.

Other Bedroom Ideas: